Lee JM, Chun HJ, Choi HS, Kim ES, Seo YS, Jeen YT, et al. Selenium administration attenuates 5-Flurouracil-induced intestinal mucositis. Nutr Cancer. 2017;69:616–22.
Article
CAS
Google Scholar
Zhang T, Lu SH, Bi Q, Liang L, Wang YF, Yang XX, et al. Volatile oil from amomi fructus attenuates 5-Fluorouracil-induced intestinal mucositis. Front Pharmacol. 2017;8:786.
Article
Google Scholar
Reinke D, Kritas S, Polychronopoulos P, Skaltsounis AL, Aligiannis N, Tran CD. Herbal substance, acteoside, alleviates intestinal mucositis in mice. Gastroenterol Res Pract. 2015;2015:327872.
Article
Google Scholar
van Vliet MJ, et al. The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog. 2010;6:e1000879.
Article
Google Scholar
van Vliet MJ, Harmsen HJ, de Bont ES, Tissing WJ. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. Lancet Haematol. 2016;3:e526–36.
Article
Google Scholar
Campbell P, Friebe A, Foulstone P, Grigg A, Hempton J, Bajel A. Impact of palifermin on mucosal toxicity in autologous stem cell transplants using busulfan-melphalan conditioning chemotherapy for Hodgkin and non-Hodgkin lymphoma. Leuk Lymphoma. 2012;53:1415–6.
Article
CAS
Google Scholar
Pontoppidan PL, Shen RL, Petersen BL, Thymann T, Heilmann C, Müller K, et al. Intestinal response to myeloablative chemotherapy in piglets. Exp Biol Med (Maywood) 2014;239:94-104.
Chang CW, Lee HC, Li LH, Chiang Chiau JS, Wang TE, Chuang WH, et al. Fecal microbiota transplantation prevents intestinal injury, upregulation of toll-like receptors, and 5-Fluorouracil/oxaliplatin-induced toxicity in colorectal cancer. Int J Mol Sci. 2020;21(2): pii: E386.
Moor AE, Harnik Y, Ben-Moshe S, Massasa EE, Rozenberg M, Eilam R, et al. Spatial reconstruction of single enterocytes uncovers broad zonation along the intestinal villus axis. Cell. 2018;175:1156–1167.e15.
Article
CAS
Google Scholar
Dore MP, Pes GM, Murino A, Quarta Colosso B, Pennazio M. Small intestinal mucosal injury in patients taking chemotherapeutic agents for solid cancers. Eur J Gastroenterol Hepatol. 2017;29:568–71.
Article
CAS
Google Scholar
Okumura R, Takeda K. Maintenance of intestinal homeostasis by mucosal barriers. Inflamm Regen. 2018;38:5.
Article
Google Scholar
Araújo CV, Lazzarotto CR, Aquino CC, Figueiredo IL, Costa TB, Alves LA, et al. Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice. Braz J Med Biol Res. 2015;48:493–501.
Article
Google Scholar
Justino PF, Melo LF, Nogueira AF, Costa JV, Silva LM, Santos CM, et al. Treatment with Saccharomyces boulardii reduces the inflammation and dysfunction of the gastrointestinal tract in 5-fluorouracilinduced intestinal mucositis in mice. Br J Nutr. 2014;111:1611–21.
Article
CAS
Google Scholar
Wang J, Jia LQ, Tan HY, Pan L, Yu LL, Deng B. Effect of Shengjiang Xiexin Decoction on the repair of damaged rat intestinal mucosa after irinotecan chemotherapy. Chin J Integr Tradit West Med. 2015;35:1236–43.
Google Scholar
Yao Q, Ye X, Wang L, Gu J, Fu T, Wang Y, et al. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Int J Clin Exp Pathol. 2013;6:2342–9.
PubMed
PubMed Central
Google Scholar
Moriya C, Shida Y, Yamane Y, Miyamoto Y, Kimura M, Huse N, et al. Subcutaneous administration of sodium alginate oligosaccharides prevents salt-induced hypertension in Dahl salt-sensitive rats. Clin Exp Hypertens. 2013;35:607–13.
Article
CAS
Google Scholar
Pritchard MF, Powell LC, Jack AA, Powell K, Beck K, Florance H, et al. A low-molecular-weight alginate oligosaccharide disrupts pseudomonal microcolony formation and enhances antibiotic effectiveness. Antimicrob Agents Chemother. 2017;61:e00762–17.
Article
CAS
Google Scholar
Hu Y, Feng Z, Feng W, Hu T, Guan H, Mao Y. AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats. Biomed Pharmacother. 2019;109:1319–26.
Article
CAS
Google Scholar
Tusi SK, Khalaj L, Ashabi G, Kiaei M, Khodagholi F. Alginate oligosaccharide protects against endoplasmic reticulum- and mitochondrial-mediated apoptotic cell death and oxidative stress. Biomaterials. 2011;32:5438–58.
Article
CAS
Google Scholar
Tajima S, Inoue H, Kawada A, Ishibashi A, Takahara H, Hiura N. Alginate oligosaccharides modulate cell morphology, cell proliferation and collagen expression in human skin fibroblasts in vitro. Arch Dermatol Res. 1999;291:432–6.
Article
CAS
Google Scholar
Guo JJ, Ma LL, Shi HT, Zhu JB, Wu J, Ding ZW, et al. Alginate oligosaccharide prevents acute doxorubicin cardiotoxicity by suppressing oxidative stress and endoplasmic reticulum-mediated apoptosis. Mar Drugs. 2016;14:231.
Article
Google Scholar
Yang Y, Ma Z, Yang G, Wan J, Li G, Du L, et al. Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microrna-29b in aneurysm patients after endovascular aortic repair. Drug Des Devel Ther. 2017;11:2565–79.
Article
CAS
Google Scholar
Zhao Y, Feng Y, Liu M, Chen L, Meng Q, Tang X, et al. Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis. Mucosal Immunol. 2020. https://doi.org/10.1038/s41385-019-0248-z.
Villéger R, Lopès A, Carrier G, Veziant J, Billard E, Barnich N, et al. Intestinal microbiota: a novel target to improve anti-tumor treatment? Int JMol Sci. 2019;20:4584.
Article
Google Scholar
Aarnoutse R, Ziemons J, Penders J, Rensen SS, de Vos-Geelen J, Smidt ML. The clinical link between human intestinal microbiota and systemic cancer Therapy. Int J Mol Sci. 2019;20:4145.
Article
Google Scholar
Alexander JL, et al. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol. 2017;14:356–65.
Article
CAS
Google Scholar
Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, et al. Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019;25(8):1225–33.
Article
CAS
Google Scholar
Ding N, Zhang X, Zhang XD, Jing J, Liu SS, Mu YP, et al. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes. Gut 2020; pii: gutjnl-2019-319127.
van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013;368:407–15.
Article
Google Scholar
Damman CJ, Miller SI, Surawicz CM, Zisman TL. The microbiome and inflammatory bowel disease: Is there a therapeutic role for fecal microbiota transplantation? Am J Gastroenterol. 2012;107:1452–9.
Article
Google Scholar
Cheng S, Ma X, Geng S, Jiang X, Li Y, Hu L, et al. Fecal microbiota transplantation beneficially regulates intestinal mucosal autophagy and alleviates gut barrier injury. mSystems 2018;3(5):pii: e00137-18.
Sun MF, Zhu YL, Zhou ZL, Jia XB, Xu YD, Yang Q, et al. Neuroprotective effects of fecal microbiota transplantation on MPTP induced Parkinson’s disease mice: gut microbiota, glial reaction and TLR4/TNFa signaling pathway. Brain Behav Immun. 2018;70:48–60.
Article
CAS
Google Scholar
Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, et al. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med. 2019;25(3):448–53.
Article
CAS
Google Scholar
Bárcena C, Valdés-Mas R, Mayoral P, Garabaya C, Durand S, Rodríguez F, et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat Med. 2019;25(8):1234–42.
Article
Google Scholar
Bouter KE, van Raalte DH, Groen AK, Nieuwdorp M. Role of the gut microbiome in the pathogenesis of obesity and obesity-related metabolic dysfunction. Gastroenterology. 2017;152(7):1671–8.
Article
CAS
Google Scholar
Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23(7):859–68.
Article
CAS
Google Scholar
Zhao Y, Zhang P, Ge W, Feng Y, Li L, Sun Z, et al. Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis. Theranostics. 2020;10(7):3308–24. https://doi.org/10.7150/thno.43189.
Article
PubMed
PubMed Central
Google Scholar
Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, et al. Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biol. 2017;18(1):70.
Article
Google Scholar
Brunse A, Martin L, Rasmussen TS, Christensen L, Skovsted Cilieborg M, Wiese M, et al. Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs. ISME J. 2019;13(3):720–73.
Article
CAS
Google Scholar
Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, et al. A single-cell survey of the small intestinal epithelium. Nature. 2017;551:333–9.
Article
CAS
Google Scholar
Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, et al. Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol. 2017;312:G171–93.
Article
Google Scholar
Cani PD. Interactions between gut microbes and host cells control gut barrier and metabolism. Int. J. Obes. 2016;Supp 6:S28 –S31.
Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479:538–41.
Article
CAS
Google Scholar
Citi S. Intestinal barriers protect against disease. Science. 2018;359:1097–8.
Article
CAS
Google Scholar
Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, et al. Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis. Environ Health Perspect. 2014;122(3):284–91.
Article
CAS
Google Scholar