Fig. 3
From: Gut microbiome signatures linked to HIV-1 reservoir size and viremia control
Associations between HIV-1 reservoir size and gut microbial signatures. Spearman’s correlations between gut microbial signatures (ratio Bacteroidales/Clostridiales, gene richness, and alpha-diversity Shannon index) and longitudinal a HIV-1 DNA (HIV-1 DNA copies/106 CD4+ T cells) and b cell-associated (CA) HIV-1 RNA (HIV-1/TBP relative expression). Positive correlations are indicated in blue and negative correlations, in red. Color and size of the circles indicate the magnitude of the correlation. White asterisks indicate significant correlations (*p < 0.05; **p < 0.01; ***p < 0.001, Benjamini–Hochberg adjustment for multiple comparisons). Boxplots showing longitudinal comparison of c HIV-1 DNA and d CA HIV-1 RNA between controllers and non-controllers. Abbreviations: MAP, monitored antiretroviral pause; pre-Vax, baseline (1 day before first MVA vaccination); MVA1, 1 week after first MVA vaccination; RMD, 1 week after third romidepsin infusion; MVA2, 4 weeks after second MVA vaccination