Fig. 6
Western diet-fed subjects display differential urine and plasma metabolites regulation based upon gut Prevotella copri abundance. Urinary biomarkers elevated in Western diet-fed P. copriHIGH subjects include carnitine-based metabolites (carnitine, acetylcarnitine, (S)-3-hydroxybutyrylcarnitine, (R)-3-hydroxybutyrylcarnitine, adipoylcarnitine (C6-DC), hexanoylcarnitine (C6), octanoylcarnitine (C8), decanoylcarnitine (C10), and laurylcarnitine (C12)), uremic toxin symmetric dimethylarginine (SDMA), homocitrulline, and 3′-sialyllactose. Plasma levels of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF) and allantoic acid were elevated between Western diet-fed P. copriHIGH and P. copriLOW subjects. n = 6-8, p < 0.05 from Welch’s two group t test. Error bars show the min to max distribution; the mean value is displayed within/next to whisker plot