Fig. 5
Western diet-fed subjects cluster into two different enterotypes based upon Prevotella copri abundance. a Proportional abundance of Prevotella copri in Mediterranean and Western diet-fed NHPs. n = 14–15, *p < 0.05 from Welch’s two group t test. Error bars show the min to max distribution. b Principal coordinates analysis (PCoA) of bacterial beta diversity based on the Bray-Curtis dissimilarity using relative abundance. P. copriHIGH samples (n=8) are shown in red circles and P. copriLOW samples are shown in orange circles. c Alpha diversity was estimated with the Shannon index on raw OTU abundance based upon P. copri abundance. Shannon diversity is significantly higher in P. copriLOW animals. d Relative abundance of bacterial species in different fecal samples is visualized by bar plots. Each bar represents a subject and each colored box a bacterial taxon. The height of a color box represents the relative abundance of that organism within the sample. “Other” represents lower abundance taxa. e Proportional abundance of Eubacterium siraeum is elevated in P. copriLOW subjects. P copriHIGH samples are characterized by elevated Faecalibacterium prausnitzii (f), Prevotella stercorea (g), Prevotella brevis (h), Bacteroides ovatus (i), and Bacteroides faecis (j). n=6-8; *p<0.05 from Welch’s two group t test