Fig. 1
From: Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs
Discovery of a new hybrid plasmid pGD17-2 that comprises the mcr-1 gene. The full genome of pGD17-2 is sequenced and collinearly compared with the counterpart of pHNSHP45 and pHUSEC2011-2. The mosaic plasmid pGD17-2 (highlighted in purple) is isolated from a colistin-resistant strain GD17. The mcr-1-positive IncI2-type plasmid pHNSHP45 and the mcr-1-negative plasmid pHUSEC2011-2 both are applied to define the plasmid backbone of pGD17-2, giving the presence of two incompatible replicon types (IncFIB and IncI2). The relevant parts of plasmid are also shown to highlight the syntenic regions. Regions of synteny between adjacent schematics are indicated by the shaded areas. These schematics are drawn to scale. Genes associated with the tra and pil loci are indicated by light blue arrows, while replication-associated genes are denoted as dark blue arrows. The mcr-1 gene is indicated with the red arrow, while accessory genes are indicated by black arrows. Insertion sequences are highlighted in green arrows