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Table 4 Results of SIMPER analysis comparing the microbiota in children with PBB and CSLD

From: The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx

Site OTU BLASTn (% identity)
Lower airway data Otu00003 Moraxella catarrhalis (98)
Otu00002 Haemophilus influenzae (99)
Otu00004 Prevotella sp. (98)
Otu00001 Mitis Group Streptococci (99)
Otu00011 Neisseria lactamica (99)
Otu00010 Neisseria sp. (99)
Otu00005 Haemophilus haemolyticus (99)
Otu00006 Porphyromonas sp. (99)
Otu00009 Prevotella melaninogenica (100)
Otu00030 Leptotrichia sp.(88)*
Upper Airway Data Otu00003 Moraxella catarrhalis (98)
Otu00002 Haemophilus influenzae (99)
Otu00001 Mitis Group Streptococci (99)
Otu00004 Prevotella sp. (98)
Otu000012 Corynebacterium propinquum (100)
Otu00005 Haemophilus haemolyticus (99)
Otu00008 Staphylococcus aureus (100)
Otu00006 Porphyromonas sp. (99)
Otu000010 Neisseria sp. (99)
Otu000017 Moraxella lincolnii (98)
  1. SIMPER analysis was performed to determine the OTUs that contributed most to the observed significant dissimilarity in the microbiota between diagnostic groups. Results are shown for the 10 OTUs in the lower and upper airway data that contributed most to the differences between children with CSLD and PBB. In comparison of children with CSLD or PBB, these OTUs contributed 30 and 26 % of the observed variation in the lower and upper airway microbiota, respectively. Comparisons with control children were not done as too few control children (n = 5) had paired upper and lower airway data to allow robust assessment of explanatory variables. OTUs are listed in a decreasing order of variation explained. BLASTn identities were selected based on 100 % coverage and >98 % identity score (% identity). OTU00030 was identified by BLASTn as Leptotrichia (*), but with only 88 % identity