Fig. 5

Gut microbiota fluctuated with altitude is associated with purine metabolism. A Similar to Fig. 4B, significantly differential KO genes involved in purine metabolism are shown in pathway modules modified from KEGG pathway maps “Inosine monophosphate biosynthesis” and “Purine degradation.” Bar plots show relative gene abundances in different groups. B Plasma metabolite levels analyzed by widely targeted mass spectrometry in different groups. C Plasma UA levels detected by clinical test. The statistical significance between two groups is marked by plus signs. The q values < 0.05 denoted as “ + ”; the q values < 0.01 denoted as “ +  + ”; the q values < 0.001 denoted as “ +  +  + .” D Pearson correlation analysis between relative abundance of genes and purine metabolites levels. E Pearson correlation analysis between relative abundance of genes and plasma UA levels