Fig. 3

Bacterial signal recognition in the placenta. Levels of expression of 10 toll-like receptors (TLRs) in the placenta are shown in A. The y-axis represents log(2)-transformed concentrations. Bars with the same symbol are significantly different (p < 0.05, Dunn’s test). Co-occurrence networks between pattern recognition receptors and microbial genes in each group are shown in B–D. Full-term delivery is shown in B, pre-term delivery in C, and pre-term delivery complicated by pre-eclampsia in D. Each network graph contains nodes (circles) and edges (lines). Nodes represent TLRs and KEGG-annotated genes, and edges represent Spearman’s ρ. Edges are colored green for positive correlation and red for negative correlation. Only significant correlations (p < 0.05, t-test) with a coefficient of at least 0.80 are shown