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Fig. 7 | Microbiome

Fig. 7

From: Multi-omics reveal mechanisms of high enteral starch diet mediated colonic dysbiosis via microbiome-host interactions in young ruminant

Fig. 7

Crosstalk between microbiome and host mucosa in enteral starch content-associated colonic inflammation of HES goats. HES diet caused increased starch content and concentrations of BAs in the colon and inhibited host mucosal MUC2 expression and epithelia tight junction, weakening the epithelia barrier. Colonic microbiome and its metabolites stimulated TH2-mediated inflammatory process in colonic mucosa. Red rectangle, upregulation; blue rectangle, downregulation. Red arrow, increase; blue arrow, decrease. Abbreviations: DUOX2, dual oxidase 2; DAO, diamine oxidase; LPS, Lipopolysaccharide; TRAV, T cell receptor alpha chain V region; c-Maf, Transcription factor Maf; C4BPA, Complement component 4 binding protein alpha; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GATA3, master transcription factor. ko04612, Antigen processing and presentation; ko04610, Complement and coagulation cascades; ko05321, Inflammatory bowel disease (IBD)

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Microbiome

ISSN: 2049-2618

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