Fig. 6

Transplantation of dysregulated gut microbiota directly induces development of depression-like behaviors. A After 1 week of acclimation, mice were randomly divided into four groups as follows: Control, Control + FMT(CUMS), CUMS and CUMS + FMT(XYS). B Body weight (SPF mice). C SPT (SPF mice). D OFT (Total distance moved) (SPF mice). E TST (SPF mice). F EPM (SPF mice). G Y-maze (SPF mice). H Movement trajectories of mice in OFT, EPM (SPF mice). I Study design for the GF mice. J OFT (GF mice). K TST (GF mice). L NORT (GF mice). M EPM (GF mice). N Movement trajectories of mice in OFT, EPM (GF mice). Data represent the mean ± SEM (n = 10 per group for SPF mice; n = 6 per group for GF mice). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus the Control group; ^#P < 0.05, ^##P < 0.01 versus the CUMS group