Skip to main content
Fig. 5 | Microbiome

Fig. 5

From: Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

Fig. 5

Complement C3/CR3 activation and complement-involved microglia-mediated aberrant synaptic pruning are important pathological manifestations of depression. A LPS in serum. B C3 in serum. C The protein expression level of C3 in PFC. D Immunofluorescence of microglia and CR3. E The expression of IBA-1 protein in PFC. F The expression of CR3 protein in PFC. G The protein expression level of SYN and PSD95 in PFC. Data represent the mean ± SEM (n = 6 per group for ELISA; n = 3 per group for IF and WB). **P < 0.01, ***P < 0.001 versus the Control group; #P < 0.05, ###P < 0.001 versus the CUMS group

Back to article page

Microbiome

ISSN: 2049-2618

Contact us