Fig. 4

Depression-like behaviors are accompanied by dysbiosis in gut homeostasis, and antidepressants restore gut homeostasis. A Alpha diversity shown by Shannon index. B PCoA. C Gut microbiota change at phylum level (barplot). D Gut microbiota change at phylum level (circos). E,F Cladogram (Gut microbiota change at the family level). The relative abundances of G: Bacteroides spp.; H Klebsiella spp.; I Lactobacillus. J Changes in gut microbial metabolites(PLS-DA). K Spearman’s correlation analysis of microbiome and metabolome. Data represent the mean ± SEM (n = 6 per group). ^**P < 0.01, ^***P < 0.001 versus the Control group; ^#P < 0.05, ^###P < 0.001 versus the CUMS group