Fig. 4

IPA rescued the social novelty deficits and cognitive impairment in 16p11.2\({}^{+/-}\) mice. A Schematic diagram for experimental design. B Representative trajectories of mice in the social novelty phase of the TCT. C IPA rescued social novelty deficits of 16p11.2\({}^{+/-}\) mice in the TCT (WT + Vehicle: n = 20 mice; WT + IPA: n = 20 mice; 16p11.2\({}^{+/-}\) + Vehicle: n = 18 mice; 16p11.2\({}^{+/-}\) + IPA: n = 18 mice. Two-way ANOVA). D IPA improved social interaction time of 16p11.2\({}^{+/-}\) mice in the DSI test (WT + Vehicle: n = 14 mice; WT + IPA: n = 15 mice; 16p11.2\({}^{+/-}\) + Vehicle: n = 14 mice; 16p11.2\({}^{+/-}\) + IPA: n = 14 mice. Two-way ANOVA). E Representative trajectories of mice in the recognition phase of the NOR test. F IPA restored cognitive impairment of 16p11.2\({}^{+/-}\) mice but had no significant effect on WT mice in NOR test (WT + Vehicle: n = 20 mice; WT + IPA: n = 20 mice; 16p11.2\({}^{+/-}\) + Vehicle: n = 18 mice; 16p11.2\({}^{+/-}\) + IPA: n = 18 mice, Two-way ANOVA). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, and n.s.: not significant. Detailed statistical information is presented in Additional file 2: Table S1