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Fig. 2 | Microbiome

Fig. 2

From: Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation

Fig. 2

Effect of OttaBac® on neuronal activation and glucocorticoid receptors of the prefrontal cortex. a Histogram showing the decrease of c-fos+ cells number in the MSPLA group, when compared to their nMSPLA counterpart, and the increase of c-fos+ cells number in the OB-treated group MSOB when compared to their respective MSPLA counterpart, in the prefrontal cortex. b Representative images showing the distribution of c-fos+ cells (in red) in the prefrontal cortex of mice, in the four experimental groups. c Histogram indicating the comparable total number of GR+ cells in the prefrontal cortex among the groups. Number of animals/group = 5. d and e GR and GAPDH expression and results from densitometric analyses of the bands show a significant increase in the amount of receptor in the MSOB group compared to the nMSPLA, MSPLA, and nMSOB groups, in the prefrontal cortex. Number of animals = 4 (MSPLA, nMSOB, MSOB), 3 nMSPLA statistical significance: *p < 0.05, **p < 0.01, and ***p < 0.001. Two-way ANOVA analysis, by Bonferroni post hoc tests. Scale bar: 100 μm. GR, glucocorticoid receptor

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Microbiome

ISSN: 2049-2618

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