Fig. 10

Mechanisms of PEDV infection alleviation by the gut microbes. Bile acids are produced in the liver and enter the intestine via the digestive system. Once in the intestine, primary bile acids may be broken down into LCA by the bacteria Lactobacillus amylovorus and Lactobacillus reuteri by increasing their expression of 7-alpha-hydroxylsteroid dehydrogenase and choloylglycine hydrolase to thus catabolize bile acids to LCA. LCA increases SLA-I expression in porcine intestinal epithelial cells via FXR, which allows accelerated recruitment of CD8⁺ CTLs to PEDV-infected target cells, followed by efficient clearance of target cells by releasing killing factors such as granzyme and perforin, thereby alleviating PEDV infection. The mechanisms diagram was created using BioRender.com