Fig. 7

Insect and bacterial factors involved in the clearance of bacteria. A Schematic profiles of expression of host regulatory pathway Hippo, host effectors involved in exocytosis, endocytosis, and autophagy as well as bacterial stress response genes depict a complex but coordinated regulation between both symbiotic partners. We also included the bacterial perceived iron availability (as predicted by the expression of iron sensing genes from Fig. 6). B Selection of deregulated pro-survival pro-apoptotic/pro-autophagic genes from the cereal weevil as well as all cytoplasmic chaperonins involved in stress response from the endosymbiont throughout the life cycle of the cereal weevil (dual RNA-seq) and/or differentially expressed between symbiotic and aposymbiotic insects (RNA-seq). Stars indicate in which stages we detected a significant upregulation (purple) or downregulation (gray) in symbiotic insects when compared to aposymbiotic within the RNA-seq dataset