Fig. 3

FMT-dd reshaped the gut microbiota then induced dyslipidemia in mice, and combination with HD promoted the phenotypes. a Experiment schematic. b Body weight gain. c Liver index level. d The serum TC, TG, HDL-C, and LDL-C levels. e The GLU level. f Liver pictures and H&E staining digital images. g PCoA plot and hierarchical clustering of OTUs based on the Bray–Curtis similarity. h Change in the ratio of Firmicutes to Bacteroidetes. i The relative abundance of differential genera between the NC and FMT-dd + ND groups. j The relative abundance of differential genera between the FMT-dd + ND and FMT-dd + HD groups. Differences of data were calculated by the unpaired T-test and one-way ANOVA in the GraphPad software. All box and whiskers plots showed the box (min to max), the median value (in the transverse line), and the whiskers (go down to the smallest value and up to the largest). Source data are provided as a Source data file. *p < 0.05, **p < 0.01, ***p < 0.001. Normal control group (NC); fecal microbiota transplantation (FMT); normal diet (ND); high-fat diet (HD); total cholesterol (TC); triglycerides (TG); high-density lipoprotein-cholesterol (HDL-C); low-density lipoprotein-cholesterol (LDL-C); serum glucose (GLU); principal coordinate analysis (PCoA); operational taxonomic units (OTU)