Fig. 3
From: Multi-site microbiota alteration is a hallmark of kidney stone formation
Stone-former gut microbiota differs from healthy controls. A PCA was performed on CLR-transformed Aitchison distances of metagenomic taxonomic bin assemblies from HC and SF fecal samples. Each coloured point represents a sample. Distance between samples on the plot represents differences in microbial community composition, with 18.2% of total variance being explained by the first two components shown. Points are coloured by sample type and ellipses represent the 95% confidence intervals of sample types. Samples significantly differed by cohort (envfit P value < 0.1). B Shannon’s Index of alpha diversity was significantly decreased in SF. C Gini coefficient of community inequality was significantly elevated in SF. Mann–Whitney tests, *P < 0.05, ***P < 0.001. Data represent the median, IQR, and minimum/maximum; HC (n = 25), SF (n = 36)