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Fig. 2 | Microbiome

Fig. 2

From: Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection

Fig. 2

Oral administration of L. paracasei MI29 protects the host from influenza infection. a Changes in body weight of mice after A/PR8 infection. b Viral titers of lung tissue measured by plaque assay using the MDCK cell line and expression levels of IFN-I in lung homogenate measured by ELISA at 2 dpi. c Lung tissue pathology and scores determined by H&E staining. d Heat map and mRNA levels for ISGs (Oas1, Cxcl10, Ifit1, Ifit3, Rsad2, Oasl2, Irf7, and Mx1) and pro-inflammatory cytokines (IL-1β, IL-6, and IL-18) in lung tissues. Statistical analyses were performed using one-way ANOVA with post hoc Tukey’s test. *p < 0.05, **p < 0.01, and ***p < 0.001. Data are combined from at least three independent experiments

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Microbiome

ISSN: 2049-2618

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