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Fig. 5 | Microbiome

Fig. 5

From: Integrated multi-omics analysis reveals the positive leverage of citrus flavonoids on hindgut microbiota and host homeostasis by modulating sphingolipid metabolism in mid-lactation dairy cows consuming a high-starch diet

Fig. 5

Serum lipidomics analysis. A Percentages of numbers of main lipid subclasses. B Principal component analysis (PCA) plot of total lipids. C PCA plot of serum sphingolipids (including SM, Cer, SPH). D Comparison of the contents of top eight lipid subclasses between CFE vs. CON. *P < 0.05. E Heatmap of differentially abundant serum lipids (VIP > 1, P < 0.05 and |FC|≥ 1.2). F KEGG enrichment analysis based on differentially abundant serum lipids. *P < 0.05, **P < 0.01. G The heatmap on the right depicts the correlations between differential serum sphingolipid species. Red, positive correlations; bule, negative correlations. The heatmap on the left depicts the correlations of serum IL-6, TNF-α, LPS, fecal Bacteroides with differential serum sphingolipid species. Green, positive correlations; purple, negative correlations. CON, control; CFE, citrus flavonoid extract; VIP, variable importance in projection; FC, fold change; LPS, lipopolysaccharide

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Microbiome

ISSN: 2049-2618

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