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Fig. 7 | Microbiome

Fig. 7

From: The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

Fig. 7

Diagram for the amelioration of gut metabolite 3-Hydroxyphenylacetic acid on the aging-related spermatogenic dysfunction. The altered GM abundance in intestine were closely related to the changed gut bacteria-derived metabolite, 3-Hydroxyphenylacetic acid (3-HPAA). 3-HPAA promotes GPX4-mediated reduction of intracellular phospholipid hydroperoxides (PL-OOH) and 3-HPAA-related metabolic pathway may alleviate the impaired spermatogenesis of aging mice through regulation of ferroptosis

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Microbiome

ISSN: 2049-2618

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