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Fig. 6 | Microbiome

Fig. 6

From: Understanding the “individual drug reaction” from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo

Fig. 6

Probiotics increased the SCFAs produced by microbes, and SCFAs could regulate the expression of liver genes. A The five intestinal bacteria increased by the three probiotics groups were positively correlated with acetic acid, propionic acid, butyric acid, and isobutyric acid (r > 0.5). The thickness of the solid line indicates the strength of the correlation. B Comparing the L + A5 group with the Lov group, the L + C3 group with the Lov group, and the L + LcS group with the Lov group, there were 92 identical differentially expressed genes (|Log2FoldChange|≥ 1, p < 0.05). C Correlation between 92 differential genes (upregulated genes and downregulated genes) and SCFAs. Genes in red: | r |> 0.5. (Wilcoxon rank-sum test, *p < 0.05, **p < 0.01). D Differential genes with strong correlation (| r |> 0.5) with SCFAs were enriched into two metabolic pathways. E Correlation between liver expressed genes, fecal SCFAs, and intestinal microbiota. The solid line indicated positive correlation, and the dotted line indicated negative correlation. The thickness of the line indicated the strength of the correlation

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Microbiome

ISSN: 2049-2618

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