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Fig. 2 | Microbiome

Fig. 2

From: Blocked conversion of Lactobacillus johnsonii derived acetate to butyrate mediates copper-induced epithelial barrier damage in a pig model

Fig. 2

Responses of colonic microbiome and SCFAs to dietary copper supplementation. Concentrations of colonic lactate (A), acetate (B), propionate (C), and butyrate (D). E PCoA of the colonic microbiome based on weighted UniFrac distance metrics. Significance between community structure was evaluated by PERMANOVA. Relative abundance of Lactobacillus (F) and L. johnsonii (G) in the colon. n = 6 piglets/group. H SCFA (lactate, acetate, propionate, butyrate) concentration and its association with relative abundance of L. johnsonii within the colonic digesta and feces of piglets on day 28. CF copper-free, CR copper-rich. Values are shown as mean and error bars represent SEM. Statistical significance was determined using two-tailed t test. *p < 0.05, **p < 0.01, ***p < 0.001

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