Fig. 4

DNA damage pattern analysis. Quality-controlled sequence reads were mapped onto assembled contigs (> 1 kbp). The damage pattern analysis was carried out with mapdamage (v.2.2.1) [69]. The plots show the substitution frequency (5pCtoT [5' cytosine to thymine substitutions], 3pGtoA [3' guanine to adenine substitutions]) versus the relative position (from the 5p and 3p end). n, number of contigs > 1 kbp considered for the analysis; cov, mean coverage of the contigs