Fig. 4

Genome-wide association of sheep genetics and heritable rumen microbial variations. Manhattan plot of host genomic associations with microbial features with at least one genome-wide significant association (P < 1 × 10⁻⁶). The y-axis shows the −log10 transformation of the association P-value observed at each tested variant. The x-axis shows the genomic position of variants. The thresholds of study-wide (0.05/N_SNPs; P = 2.163378e-09) and genome-wide (P = 1 × 10⁻⁸) significance are shown with horizontal lines. The autosome variants were annotated by Ensembl Variant Effect Predictor