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Table 1 Demographics and infection characteristics of the participants included in this study

From: Unique microbial landscape in the human oropharynx during different types of acute respiratory tract infections

Level

Overall

Healtha

FluA

FluB

HRV

RSV

FluA/FluB

FluA/FluB/HRV

FluA/FluB/RSV

FluA/HRV

FluA/RSV

FluB/HRV

FluB/RSV

FluB/HRV/RSV

HRV/RSV

FluA/FluB/HRV/RSV

n

447

98

22

138

61

34

16

4

12

3

13

22

16

3

3

2

BMI (*Significant P.adj)

  

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

 Median [IQR], kg/m2

21.22 [19.04, 23.88]

20.50 [18.72, 22.58]

22.34 [19.38, 23.80]

21.48 [19.22, 24.49]

20.31 [19.13, 23.48]

22.60 [18.73, 26.12]

20.76 [19.76, 21.34]

22.50 [21.96, 29.50]

26.37 [19.16, 29.42]

19.13 [18.93, 23.34]

20.74 [18.79, 24.34]

21.10 [18.94, 22.70]

21.16 [19.33, 24.08]

20.72 [20.36, 31.38]

23.44 [20.91, 32.35]

22.19 [21.32, 23.07]

Sex (*Significant P.adj)

  

*

*

*

*

*

*

*

*

ns

*

*

ns

ns

ns

 Female, n (%)

264 (59.1)

88 (89.8)

11 (50.0)

72 (52.2)

30 (49.2)

19 (55.9)

5 (31.2)

1 (25.0)

6 (50.0)

1 (33.3)

9 (69.2)

10 (45.5)

7 (43.8)

2 (66.7)

2 (66.7)

1 (50.0)

 Male, n (%)

178 (39.8)

8 ( 8.2)

11 (50.0)

66 (47.8)

30 (49.2)

14 (41.2)

11 (68.8)

2 (50.0)

6 (50.0)

2 (66.7)

4 (30.8)

12 (54.5)

9 (56.2)

1 (33.3)

1 (33.3)

1 (50.0)

Ageb (*Significant P.adj)

  

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

ns

 Median [IQR], years

29.00 [23.50, 35.00]

31.50 [24.75, 38.00]

29.00 [27.00, 37.50]

29.00 [24.00, 35.00]

26.00 [22.00, 32.00]

30.00 [25.00, 36.00]

29.00 [26.50, 31.00]

30.50 [28.25, 32.75]

29.00 [27.00, 32.25]

43.00 [37.50, 56.50]

34.00 [28.00, 55.00]

26.50 [22.50, 30.00]

21.00 [19.00, 25.75]

23.00 [20.50, 26.00]

47.00 [36.50, 54.50]

23.50 [20.25, 26.75]

Vaccine (*Significant P.adj)

 

ns

ns

ns

ns

ns

ns

ns

ns

*

ns

ns

ns

*

ns

 No, n (%)

347 (77.6)

74 (75.5)

15 (68.2)

106 (76.8)

50 (82.0)

29 (85.3)

12 (75.0)

4 (100.0)

10 (83.3)

2 (66.7)

9 (69.2)

20 (90.9)

11 (68.8)

1 (33.3)

2 (66.7)

2 (100.0)

 Yes, n (%)

80 (17.9)

24 (24.5)

6 (27.3)

24 (17.4)

7 (11.5)

5 (14.7)

3 (18.8)

0 ( 0.0)

1 ( 8.3)

1 (33.3)

1 ( 7.7)

1 ( 4.5)

5 (31.2)

2 (66.7)

0 ( 0.0)

0 ( 0.0)

Chronic respiratory diseases (*Significant P.adj)

 

ns

ns

ns

ns

ns

ns

ns

ns

*

ns

ns

ns

ns

ns

 No, n (%)

345 (77.2)

86 (87.8)

18 (81.8)

101 (73.2)

44 (72.1)

27 (79.4)

12 (75.0)

3 (75.0)

9 (75.0)

1 (33.3)

10 (76.9)

16 (72.7)

12 (75.0)

2 (66.7)

2 (66.7)

2 (100.0)

 Yes, n (%)

93 (20.8)

12 (12.2)

4 (18.2)

33 (23.9)

16 (26.2)

7 (20.6)

3 (18.8)

1 (25.0)

3 (25.0)

2 (66.7)

1 ( 7.7)

5 (22.7)

4 (25.0)

1 (33.3)

1 (33.3)

0 ( 0.0)

  1. Continuous Variables are presented as median (interquartile range) unless otherwise indicated
  2. Chronic respiratory diseases: lung cancer, chronic obstructive pneumonia disease, bronchitis, idiopathic pulmonary fibrosis
  3. IQR Interquartile range, BMI Body mass index, FluA Influenza A virus, FluB Influenza B virus, RSV Respiratory syncytial virus, HRV Human rhinovirus
  4. *Significant P.adjust (Bonferroni P.adjust < 0.05) were calculated by using the Mann-Whitney U test or the Fisher exact test between subjects with one specific virus to the healthy controls; ns, non-significant
  5. aHealthy controls of this study were recruited from paramedics at the same community hospitals in this study
  6. bAge stratification of this cohort included adolescents (13-18 years, n = 53) and adults (19 years and older, n = 372)
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Microbiome

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