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Fig. 9 | Microbiome

Fig. 9

From: Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice

Fig. 9

Ri. treatment improved the perturbation of neurotransmitters from the Trp-Kyn metabolic pathway in mouse brains and colons. A Levels of 5-HT and KP metabolites in the PFCs of the mice. B Levels of 5-HT and KP metabolites in the colons of the mice. C Protein expression of the rate-limiting enzymes of KP metabolism in the mice PFCs and colons. D The statistical plots of the PFCs. E The statistical plots of the colon. Data were displayed as mean ± SEM. Significant differences were determined via two-way ANOVA and Tukey’s multiple comparison procedure. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. the CTR + PBS group; &p < 0.05, &&p < 0.01, &&&&p < 0.0001 vs. the CTR + Ri group; #p < 0.05, ##p < 0.01, ####p < 0.0001 vs. the CRS + PBS group

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Microbiome

ISSN: 2049-2618

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