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Fig. 2 | Microbiome

Fig. 2

From: Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice

Fig. 2

Alterations of Trp-Kyn pathway-derived metabolites in both serum and urine samples after antidepressant treatment. A Levels of dopamine and partial Trp-Kyn pathway metabolites in serum samples from depressive adolescents before and after sertraline treatment. B Levels of 5-HT and Trp-Kyn pathway metabolites in urine samples from depressive adolescents before and after sertraline treatment. Data were displayed as mean ± SEM. Significant differences before and after sertraline treatment were determined using Student’s t tests for serum 5-HT, Quin, and urine Trp, while Mann-Whitney U tests employed for other components. ***p < 0.001, ****p < 0.0001 vs. the DEP group

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Microbiome

ISSN: 2049-2618

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