Table 4 KEGG Pathway annotation of positional candidate genes at Mtq7, Mtq8, Mtq13, Mtq14, and Pc1q
QTL | Model | Phenotype | Gene symbol (MGI) | KEGG pathway |
|---|---|---|---|---|
Bcpc2q | Combined y ~ m + sex*diet | Bray Curtis PC2 | Aim2 | Cytosolic DNA-sensing pathway (mmu04623) |
| Â | Â | Â | Akt3 | Adipocytokine signaling pathway (mmu04920) |
| Â | Â | Â | Akt3 | AMPK signaling pathway (mmu04152) |
| Â | Â | Â | Akt3 | Carbohydrate digestion and absorption (mmu04973) |
| Â | Â | Â | Akt3 | Chemokine signaling pathway (mmu04062) |
| Â | Â | Â | Akt3 | Epstein-Barr virus infection (mmu05169) |
| Â | Â | Â | Akt3 | Hepatitis B (mmu05161) |
| Â | Â | Â | Akt3 | Hepatitis C (mmu05160) |
| Â | Â | Â | Akt3 | HIF-1 signaling pathway (mmu04066) |
| Â | Â | Â | Akt3 | Influenza A (mmu05164) |
| Â | Â | Â | Akt3 | Insulin resistance (mmu04931) |
| Â | Â | Â | Akt3 | Insulin signaling pathway (mmu04910) |
| Â | Â | Â | Akt3 | Measles (mmu05162) |
| Â | Â | Â | Akt3 | Non-alcoholic fatty liver disease (NAFLD) (mmu04932) |
| Â | Â | Â | Akt3 | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Akt3 | Prolactin signaling pathway (mmu04917) |
| Â | Â | Â | Akt3 | Regulation of lipolysis in adipocytes (mmu04923) |
| Â | Â | Â | Akt3 | T cell receptor signaling pathway (mmu04660) |
| Â | Â | Â | Akt3 | Tight junction (mmu04530) |
| Â | Â | Â | Akt3 | Toll-like receptor signaling pathway (mmu04620) |
| Â | Â | Â | Akt3 | Tuberculosis (mmu05152) |
| Â | Â | Â | Aldh9a1 | Glycolysis/gluconeogenesis (mmu00010) |
| Â | Â | Â | Alyref2 | Herpes simplex virus 1 infection A (mmu05168) |
| Â | Â | Â | Apoa2 | PPAR signaling pathway (mmu03320) |
| Â | Â | Â | Atp1a2 | Bile secretion (mmu04976) |
| Â | Â | Â | Atp1a2 | Carbohydrate digestion and absorption (mmu04973) |
| Â | Â | Â | Atp1a2 | Mineral absorption (mmu04978) |
| Â | Â | Â | Atp1a2 | Protein digestion and absorption (mmu04974) |
| Â | Â | Â | Atp1a4 | Bile secretion (mmu04976) |
| Â | Â | Â | Atp1a4 | Carbohydrate digestion and absorption (mmu04973) |
| Â | Â | Â | Atp1a4 | Mineral absorption (mmu04978) |
| Â | Â | Â | Atp1a4 | Protein digestion and absorption (mmu04974) |
| Â | Â | Â | Atp1b1 | Bile secretion (mmu04976) |
| Â | Â | Â | Atp1b1 | Carbohydrate digestion and absorption (mmu04973) |
| Â | Â | Â | Atp1b1 | Mineral absorption (mmu04978) |
| Â | Â | Â | Atp1b1 | Protein digestion and absorption (mmu04974) |
| Â | Â | Â | Cadm3 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Cd244a | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Cd247 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Cd247 | T cell receptor signaling pathway (mmu04660) |
| Â | Â | Â | Cd48 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Ephx1 | Bile secretion (mmu04976) |
| Â | Â | Â | F11r | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | F11r | Leukocyte transendothelial migration (mmu04670) |
| Â | Â | Â | F11r | Tight junction (mmu04530) |
| Â | Â | Â | Fasl | African trypanosomiasis (mmu05143) |
| Â | Â | Â | Fasl | Allograft rejection (mmu05330) |
| Â | Â | Â | Fasl | Autoimmune thyroid disease (mmu05320) |
| Â | Â | Â | Fasl | Hepatitis B (mmu05161) |
| Â | Â | Â | Fasl | Herpes simplex virus 1 infection A (mmu05168) |
| Â | Â | Â | Fasl | Influenza A (mmu05164) |
| Â | Â | Â | Fasl | Measles (mmu05162) |
| Â | Â | Â | Fasl | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Fasl | Non-alcoholic fatty liver disease (NAFLD) (mmu04932) |
| Â | Â | Â | Fasl | Type I diabetes mellitus (mmu04940) |
| Â | Â | Â | Fcer1g | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Fcer1g | Tuberculosis (mmu05152) |
| Â | Â | Â | Fcgr2b | Measles (mmu05162) |
| Â | Â | Â | Fcgr2b | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Fcgr2b | Staphylococcus aureus infection (mmu05150) |
| Â | Â | Â | Fcgr2b | Tuberculosis (mmu05152) |
| Â | Â | Â | Fcgr3 | Leishmaniasis (mmu05140) |
| Â | Â | Â | Fcgr3 | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Fcgr3 | Staphylococcus aureus infection (mmu05150) |
| Â | Â | Â | Fcgr3 | Tuberculosis (mmu05152) |
| Â | Â | Â | Fcgr4 | Leishmaniasis (mmu05140) |
| Â | Â | Â | Fcgr4 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Fcgr4 | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Fcgr4 | Staphylococcus aureus infection (mmu05150) |
| Â | Â | Â | Fcgr4 | Systemic lupus erythematosus (mmu05322) |
| Â | Â | Â | Fcgr4 | Tuberculosis (mmu05152) |
| Â | Â | Â | H3f3a | Systemic lupus erythematosus (mmu05322) |
| Â | Â | Â | Hsd17b7 | Ovarian steroidogenesis (mmu04913) |
| Â | Â | Â | Hsd17b7 | Steroid biosynthesis (mmu00100) |
| Â | Â | Â | Hsd17b7 | Steroid hormone biosynthesis (mmu00140) |
| Â | Â | Â | Ifi202b | Cytosolic DNA-sensing pathway (mmu04623) |
| Â | Â | Â | Mpz | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Mpzl1 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Ndufs2 | Non-alcoholic fatty liver disease (NAFLD) (mmu04932) |
| Â | Â | Â | Pex19 | Peroxisome (mmu04146) |
| Â | Â | Â | Rxrg | Adipocytokine signaling pathway (mmu04920) |
| Â | Â | Â | Rxrg | PPAR signaling pathway (mmu03320) |
| Â | Â | Â | Sdhc | Non-alcoholic fatty liver disease (NAFLD) (mmu04932) |
| Â | Â | Â | Sele | African trypanosomiasis (mmu05143) |
| Â | Â | Â | Sele | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Sell | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Selp | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Selp | Staphylococcus aureus infection (mmu05150) |
| Â | Â | Â | Sh2d1b1 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Slamf1 | Measles (mmu05162) |
| Â | Â | Â | Tlr5 | Inflammatory bowel disease (mmu05321) |
| Â | Â | Â | Tlr5 | Salmonella infection (mmu05132) |
| Â | Â | Â | Tlr5 | Toll-like receptor signaling pathway (mmu04620) |
| Â | Â | Â | Xcl1 | Chemokine signaling pathway (mmu04062) |
Wufpc1q | Diet specific y ~ sex + diet*m | Weighted UniFraction PC1 | Cldn14 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Cldn14 | Hepatitis C (mmu05160) |
| Â | Â | Â | Cldn14 | Leukocyte transendothelial migration (mmu04670) |
| Â | Â | Â | Cldn14 | Tight junction (mmu04530) |
| Â | Â | Â | Cldn17 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Cldn17 | Hepatitis C (mmu05160) |
| Â | Â | Â | Cldn17 | Leukocyte transendothelial migration (mmu04670) |
| Â | Â | Â | Cldn17 | Tight junction (mmu04530) |
| Â | Â | Â | Cldn8 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Cldn8 | Hepatitis C (mmu05160) |
| Â | Â | Â | Cldn8 | Leukocyte transendothelial migration (mmu04670) |
| Â | Â | Â | Cldn8 | Tight junction (mmu04530) |
| Â | Â | Â | Cxadr | Viral myocarditis (mmu05416) |
| Â | Â | Â | Ifnar1 | Hepatitis B (mmu05161) |
| Â | Â | Â | Ifnar1 | Hepatitis C (mmu05160) |
| Â | Â | Â | Ifnar1 | Herpes simplex virus 1 infection A (mmu05168) |
| Â | Â | Â | Ifnar1 | Influenza A (mmu05164) |
| Â | Â | Â | Ifnar1 | Measles (mmu05162) |
| Â | Â | Â | Ifnar1 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Ifnar1 | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Ifnar1 | Toll-like receptor signaling pathway (mmu04620) |
| Â | Â | Â | Ifnar2 | Hepatitis C (mmu05160) |
| Â | Â | Â | Ifnar2 | Herpes simplex virus 1 infection A (mmu05168) |
| Â | Â | Â | Ifnar2 | Influenza A (mmu05164) |
| Â | Â | Â | Ifnar2 | Measles (mmu05162) |
| Â | Â | Â | Ifnar2 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Ifnar2 | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Ifnar2 | Toll-like receptor signaling pathway (mmu04620) |
| Â | Â | Â | Ifngr2 | Herpes simplex virus 1 infection A (mmu05168) |
| Â | Â | Â | Ifngr2 | HIF-1 signaling pathway (mmu04066) |
| Â | Â | Â | Ifngr2 | Inflammatory bowel disease (mmu05321) |
| Â | Â | Â | Ifngr2 | Influenza A (mmu05164) |
| Â | Â | Â | Ifngr2 | Leishmaniasis (mmu05140) |
| Â | Â | Â | Ifngr2 | Measles (mmu05162) |
| Â | Â | Â | Ifngr2 | Natural killer cell-mediated cytotoxicity (mmu04650) |
| Â | Â | Â | Ifngr2 | Osteoclast differentiation (mmu04380) |
| Â | Â | Â | Ifngr2 | Salmonella infection (mmu05132) |
| Â | Â | Â | Ifngr2 | Tuberculosis (mmu05152) |
| Â | Â | Â | Il10rb | Epstein-Barr virus infection (mmu05169) |
| Â | Â | Â | Il10rb | Tuberculosis (mmu05152) |
| Â | Â | Â | Jam2 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Jam2 | Leukocyte transendothelial migration (mmu04670) |
| Â | Â | Â | Jam2 | Tight junction (mmu04530) |
| Â | Â | Â | Ncam2 | Cell adhesion molecules (mmu04514) |
| Â | Â | Â | Sod1 | Peroxisome (mmu04146) |
| Â | Â | Â | Tiam1 | Chemokine signaling pathway (mmu04062) |