Table 2 Linkage analysis for microbial metadata
Phenotype | Model | Left marker | Top marker | Right marker | QTL identifier | Chr | Start (Mb) | Top (Mb) | End (Mb) | LOD § | Effect of B6/FVB alleles § | Effect of FVB/FVB alleles § | Top marker (% variance explained) | Sex (% variance explained) | Diet (% variance explained) | Sex * diet (% variance explained) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bray Curtis PCo2 | Combined y ~ m + sex*diet | UNC010637850 | backupJAX00277549 | UNC010414123 | Bcpc2q | 1 | 160.6 | 177.5 | 185.1 | 4.39b |  − 0.10 |  − 0.10 | 4.16*** | 0.15 | 10.18*** | 0.83* |
Jaccard PCo2 | Combined y ~ m + sex*diet | UNC010637850 | backupJAX00277549 | UNC010414123 | Jpc2q | 1 | 160.6 | 177.5 | 185.1 | 4.12b |  − 0.08 |  − 0.09 | 3.86*** | 0.12 | 11.65*** | 0.58 |
Unweighted UniFraction PCo2 | Combined y ~ m + sex*diet | UNC080206141 | UNC080229115 | UNC080591069 | Uufpc2q | 8 | 43.4 | 53.7 | 62.8 | 4.16b |  − 0.03 | 0.02 | 3.58*** |  < 0.01 | 15.48*** | 4.17*** |
Phenotype | Model | Left marker | Top marker | Right marker | QTL identifier | Chr | Start (Mb) | Top (Mb) | End (Mb) | LOD ⌘ | Effect of American B6/FVB alleles ⌘ | Effect of American FVB/FVB alleles ⌘ | Top marker (% variance explained) | Sex (% variance explained) | Diet (% variance explained) | Top marker * diet (% variance explained) |
Weighted UniFraction PCo1 | Diet specific y ~ sex + diet*m | UNC160227296 | UNC160235091 | UNC160983056 | Wufpc1q | 16 | 72.8 | 79.6 | 95.8 | 4.97a |  − 0.03 |  − 0.03 | 1.14** | 0.01 | 59.26*** | 2.1*** |