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Table 1 Tacrolimus (TAC) population pharmacokinetics (PK) model

From: Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1

TAC PK model

Mean

IC 95%

Primary PK parameters

Cl/F

0.32 L/h

[0.29–0.35]

V

1.88 L

[1.68–2.08]

Ka

1.20 h−1

[1.08–1.32]

Derived PK parameters

AUC0-24 h

274.4 ng h/mL

[242.2–306.5]

T½

4.08 h

[3.92–4.23]

  1. TAC primary PK parameters (oral clearance (Cl/F), volume of distribution (V), absorption rate constant (Ka)) generated from a mono-compartmental model and derived PK parameters (area under the curve (AUC0-24 h) and half-life (T ½)) (n = 351 blood samples obtained in 99 mice, as described in the ‘Pharmacokinetic analysis’ subsection of the ‘Methods’ section)
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Microbiome

ISSN: 2049-2618

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