Fig. 7
From: Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
Modulation of ABCB1A efflux activity by the gut microbiota explains differences in tacrolimus (TAC) blood exposure. TAC area under the curve (AUC) derived from the PK model in mice under control (TAC), zosuquidar (TAC + ZSQ), antibiotics (TAC + ATB), or ZSQ with ATB (TAC + ATB + ZSQ) conditions (n = 10–36/group). ***p < 0.001, **p < 0.01; ###p < 0.001 (TAC + ZOSU vs TAC + ATB + ZOSU); $$$p < 0.001 (TAC + ATB vs TAC + ATB + ZOSU)