Fig. 6
From: Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
ABCB1A inhibition reverses the gut microbiota effect on tacrolimus (TAC) pharmacokinetics (PK). A TAC blood concentration in control (TAC) or antibiotic (ATB)-treated (TAC + ATB) mice under ABCB1 inhibitor, zosuquidar (ZSQ). ***p < 0.001. B TAC area under the curve (AUC) derived from the PK model in TAC + ZSQ or TAC + ATB + ZSQ mice (n = 10–11/group). ***p < 0.001