Fig. 4
From: Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
Abcb1a expression in the small intestine correlates with tacrolimus (TAC) whole blood exposure. A Comparison of the mRNA expression of Abcb1a in the proximal, median and distal small intestine; in the colon; and in the liver of control and ATB-treated mice, with or without TAC treatment (n = 7–8/group). #significant ATB effect; $significant TAC effect; ***p < 0.001, **p < 0.01, and *p < 0.05. B Pearson’s correlation between TAC area under the curve (AUC) and Abcb1a mRNA expression level in the different tissues