Fig. 3From: Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1Antibiotic (ATB)-mediated gut microbiota depletion affects tacrolimus (TAC) pharmacokinetics (PK) and reduces TAC blood exposure. A TAC blood concentration in control (TAC) or ATB-treated mice (TAC + ATB). B TAC area under the curve (AUC) computed with the PK model for both mouse groups (n = 10/group). **p < 0.01Back to article page