Fig. 10
From: Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
mRNA expression of CAR correlates with Abcb1a levels in mouse intestine. In mice, the transcription factor CAR is encoded by the Nr1i3 gene. A Comparison of the mRNA expression of Nr1i3 in the proximal, median and distal small intestine; in the colon; and in the liver of control and ATB-treated mice, with or without TAC treatment (n = 7–8/group). #significant ATB effect; $significant TAC effect; ***p < 0.001, **p < 0.01, and *p < 0.05. B Spearman’s correlation between Nr1i3 and Abcb1a mRNA expression levels in the different tissues