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Fig. 3 | Microbiome

Fig. 3

From: Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

Fig. 3

A. muciniphila improved cognitive function in aged mice. a Heatmap of significant changes in the gut microbiota at the species level after A. muciniphila treatment. Colours on the heatmap indicate the relative abundance of gut microbiota. Red indicates upregulated bacteria, and blue indicates downregulated bacteria. b The escape latency in the A. muciniphila-treated mouse group was significantly shorter than that in the control group during the acquisition phase. c The latency to first reaching the platform in the A. muciniphila-treated group was significantly shorter than that in the control group during the probe trial. d The mean swimming velocity was not different between the A. muciniphila-treated and control groups during the probe trial. e Times of the new object touched were significantly increased in the A. muciniphila group compared with that in the control group. Ctrl, control; AKK, A. muciniphila. The overall significance between the two groups was determined by Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001; ns, not significant

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Microbiome

ISSN: 2049-2618

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