Fig. 4

CBA/J database (CBAJ-DB) genomes link to other murine and human studies. A Medium and high quality (MQHQ) metagenome assembled genomes (MAGs) that clustered with genomes from either murine databases (light purple columns) or the HMP/Human cohort (yellow columns). CBAJ-DB MAGs that were the highest quality genome in each cluster are marked with an asterisk and are displayed in the stacked bar chart grouped by database. MAGs are grouped by class (first bar annotation) and treatment origin (second bar annotation), with the lowest assigned taxonomy indicated in gray scale (right bar). For each database in black outline, blue cells indicate CBAJ-DB MAGs that clustered, while green cells show no clustering. Accompanying bar chart shows the number of CBAJ-DB MAGs with higher quality scores corresponding genomes in other databases. The MAG indicated with red font in the heatmap was determined to contain possible chimeric by GUNC but not CheckM. B CBAJ-DB MAGs that recruited human reads are shown by blue (Akkermansia muciniphila) and orange nodes (Enterococcus_D gallinarum), with size indicating number of CBAJ-DB MAGs. MAG nodes are linked to databases shown as pie charts, where green (healthy human) and tan (inflamed human) indicate sequencing origin of mapped reads and node size indicates sample number. C SRA accession ID’s of samples from the Lloyd-Price cohort that mapped to CBAJ-DB MAGs Akkermansia muciniphila (blue) or Enterococcus_D gallinarum (orange). D vContact2 network that shows 609 clustered viral metagenome assembled genomes (vMAG) populations present in CBAJ-DB. The network colors represent the vMAG study origin. Pie chart shows proportion of CBAJ-DB vMAGs that clustered to other studies that are cosmopolitan genera (brown), singletons (gray), novel genera (clusters of > 1 vMAGs from this study only, green), or known taxonomy (yellow)