Table 1 Demographic, clinical and histological data of UK cohort

N

74

Male:female

41:33

Median BMI (range)

26.5 (15.1–36.0)

Median age (range)

70 (36–91)

Ethnicity

 White

56

 Asian/Asian British

11

 Black/Black British

6

 Other

1

Smoking

 Never smoker

33

 Current smoking

9

 Previous smoking

32

Alcohol

 Non-drinker

29

 1–10 units per week

25

 10–20 units per week

13

 > 20 units per week

7

Vegetarian

3

Red meat

 < 2 portions/week

40

 2 or more portions/week

34

Family history of CRC

16

Charlson score (median)

5

Proton-pump Inhibitor use

17

Tumour site

 Rectum

23

 Sigmoid & recto-sigmoid

15

 Descending

2

 Splenic flexure

3

 Transverse

8

 Hepatic flexure

2

 Caecum & ascending colon

21

Neo-adjuvant treatment

 None

68

 Long-course chemoradiotherapy

5

 Chemotherapy alone

1

T stage

 T1/2

18

 T3

42

 T4

14

N stage

 N0

51

 N1

18

 N2

5

M stage

 M0

71

 M1

3

AJCC stage

 I

14

 II

37

 III

20

 IV

3

Differentiation

 Well

3

 Moderate

54

 Moderate–poor

4

 Poor

13

DNA mismatch repair deficiency$

14/46

Extra-mural venous invasion

27

Lymphovascular invasion

28

Tumour budding

47