Fig. 4

Integration of the colorectal cancer mucosal microbiota, metabolome and tumour driver mutations. a Correlation between individual microbiota and metabolites. Positive correlations shown in shades of red; negative correlations in shades of blue. Only statistically significant correlations are shown. Microbiota and metabolites are ordered by the clustering from the individual dataset-specific analyses. Microbiota clusters are labelled along the right side of the figure and metabolite clusters along the top with dotted lines indicating division of clusters. b Box and whisker plots showing median and 95% confidence intervals for cluster proportions in patients with ( +) and without ( −) target mutations of interest. **p-value < 0.01