Fig. 2

DI supplementation improved the transcriptome profile associated with cognition in the hippocampus of mice on HF diet. a The volcano plot shows the distributions of differentially expressed genes (DEGs) between HF+Veh and LC+Veh mice. b The volcano plot shows the distributions of DEGs between HF+DI and HF+Veh mice. c The number of upregulated and downregulated DEGs. d The biological processes associated with behavior, synaptic plasticity, and transmission are upregulated in HF diet-fed mice after DI supplementation. e The cellular components associated with synapse are upregulated in the HF+DI group in comparison to HF+Veh group. f The fpkm value, fold change and P-value of pro-cognitive DEGs of HF+Veh and HF+DI groups. g The enriched KEGG pathways related to behavior, synapse, and brain development in HF diet-fed mice after DI supplementation. Columns with different colors represent different classification in level 2. The dotted line in the figure represents P = 0.05. h PPI network analysis of pro-cognitive genes based on STRING database and Cytoscape 3.9.1. Black lines denoted the interaction between two proteins. n = 3 mice for each group