Fig. 5

Microbiota modulation is associated with initial microbiome diversity. Euclidean distance of A microbiota profiles including all sequence variants or B lipidic profile between baseline and each visit of the study for each participant in relation with their alpha diversity at baseline. Regression lines were drawn for each visit. Slope of line (lm) and Spearman correlations were considered significant only for microbiota distance measurements with p-values < 0.01. Spearman coefficients are also significant and are displayed on the legend. Red represents the distance between the microbiota profile of baseline (V1) and the first MedDiet (V2), black of baseline (V1) and CanDiet (V3), and gray of baseline (V1) and the second MedDiet (V4). C Heatmap illustrating the FDR-corrected Spearman correlations between the gut microbiota genera that were at more than 1% in at least one sample and gut microbiota diversity calculated on all sequence variants represented by Simpson’s index (1-D) at each visit and combining the four visits. D Heatmap illustrating the FDR-corrected Spearman correlations between plasmatic lipid concentrations and gut microbiota diversity calculated on all sequence variants represented by Simpson’s index (1-D) at each visit and combining the four visits. Significance was set at p<0.05 (*), p<0.01 (**), and p<0.001 (***)