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Fig. 11 | Microbiome

Fig. 11

From: Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice

Fig. 11

Cyanocobalamin-induced dysbiosis increased the production of the p40 subunit in colon tissues of mice prior to pathogen challenge. Pre-infection levels of IL-12/23p40 in colon tissues were directly related to microbiota structure and independent of related mice genotypes. a Gene expression was significantly higher for IL12B, the p40 subunit coding gene, but not for the IL-12A (p35) gene (n = 8) in the EPC experiment. b The SURV experiment did not display the increase in IL-12/23p40 (n = 5–6), nor did c germ-free C57BL/6J mice (n = 4; *P < 0.05, **P < 0.01, ***P < 0.001). d Cyanocobalamin and methylcobalamin supplementation at 10 μg/ml and 40 μg/ml increased IL/23p40 protein levels in the colon of conventional C57BL/6J mice (n = 6; P < 0.05) compared to control

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Microbiome

ISSN: 2049-2618

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