Table 1 Cohort demographics

 16S rRNA sequencing

174

312

 Metatranscriptomics

119

208

 Metabolomics

139

229

 Male

40%

23%

0.00013

 Female

60%

77%

Age

30 (23–38)

29 (23–41)

0.57

BMI

26.9 (23.4–30.2)

23.4 (21.0–26.0)

3 × 10⁻¹²

 Non-Hispanic white

31%

52%

0.00016

 Hispanic

25%

20%

 African-American

12%

7%

 Asian

21%

14%

 Multiracial

10%

7%

 Some high school

1%

1%

0.12

 High school grad

7%

6%

 Some college

28%

39%

 College grad

33%

24%

 Any postgrad

31%

30%

 Standard

79%

55%

0.0005

 Restrictive

8%

30%

 Other

13%

15%

HAD-Anxiety

3 (1–6)

7 (4–10)

8 × 10⁻¹⁴

HAD-Depression

1 (0–3)

2 (1–5)

7 × 10⁻⁶

STAI Trait Anxiety

32 (26–38)

37 (27–44)

0.0055

PILL

4 (2–7)

16 (11–22)

< 2 × 10⁻¹⁶

VSI

2 (0–8)

40 (28–54)

< 2 × 10⁻¹⁶

 IBS-D

38%

 IBS-C

35%

 IBS-M

17%

 IBS-U

9%

IBS-SSS

241 (184–312)