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Fig. 8 | Microbiome

Fig. 8

From: Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity

Fig. 8

Proposed mechanism of perturbed gut microbiome together with fecal and serum metabolites in pathogenesis of CKD progression. Perturbation of CKD severity-related gut microbiotas may interact with disbalanced toxic and pro-oxidant metabolites from arginine and proline metabolism, arachidonic acid metabolism, ubiquinone and other terpenoid-quinone biosynthesis, and glutathione metabolism to accelerate disease progression. Red arrow indicates upregulation; black arrow indicates downregulation. LTB4, leukotriene B4

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Microbiome

ISSN: 2049-2618

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