Fig. 6

Interactions between gut microbiota composition and functional metabolites in feces and blood. A Integrated network of CKD severity-related microbial species, fecal metabolites, and serum metabolites. Networks were constructed using NAMAP with Spearman’s rank correlations between the gut microbiotas. The size of nodes represented the degree of corresponding factors. Direct correlations are indicated as blue edges and inverse correlations as red edges with a cutoff of P < 0.05 and r > 0.7. B The SANKEY diagrams show associations that are statistically significant with a cutoff of P < 0.05 and r > 0.7 based on bootstrapping of 150 iterations. The blue line and red line indicate positive and negative correlations, respectively. LTB4, leukotriene B4; 12-KETE, 12-keto-5,8,10,14-eicosatetraenoic acid