Fig. 5

Network modules from weighted co-occurrence network (WCN) graphs and community state types (CST) from community state typing are associated with salivary pH among incident and pre-incident saliva samples from an incidence density-matched nested case-control study selected form the Center for Oral Health Research in Appalachia 2 cohort study. A The protective H. parainfluenzae and Neisseria ASV9 network is positively correlated with salivary pH at 12 and 24 months (n = 95 at 12 months, with n = 71 missing or outlier salivary pH data, n = 162 at 24 months with n = 10 missing salivary pH data). B Salivary pH is also lower in saliva samples that were assigned to the Neisseria ASV12-Veillonella ASV5 CST when compared to saliva samples assigned to the Haemophilus parainfluenzae–Neisseria ASV9 CST (n = 94 at 12 months, with n = 71 missing or outlier salivary pH data and n = 1 with unassigned CST, n = 162 at 24 months, with n = 10 missing salivary pH data)