Fig. 3

Single-nucleotide polymorphisms (SNPs) identified in M8 homologous isolates of mother-infant pairs. A Distribution of SNPs in the chromosome of M8. The white and gray stripes from bottom to top of the plot represent isolates of M8 dry powder (Powder), families B, D, F, G, L, J, Q, S, N, T, and X (family), respectively. B Distribution of nonsynonymous SNPs across 18 Clusters of Orthologous Genes (COG) functional categories. The letter below the horizontal ordinate represents the functional category: [G] Carbohydrate transport and metabolism; [R] General function prediction only; [E] Amino acid transport and metabolism; [L] Replication, recombination and repair; [P] Inorganic ion transport and metabolism; [M] Cell wall/membrane/envelope biogenesis; [J] Translation, ribosomal structure and biogenesis; [S] Function unknown; [K] Transcription; [C] Energy production and conversion; [F] Nucleotide transport and metabolism; [H] Coenzyme transport and metabolism; [T] Signal transduction mechanisms; [O] Posttranslational modification, protein turnover, chaperones; [I] Lipid transport and metabolism; [V] Defense mechanisms; [D] Cell cycle control, cell division, chromosome partitioning; [Q] Secondary metabolites biosynthesis, transport and catabolism C Number of SNPs detected in isolates from M8 dry powder and samples of mother-infant pairs (maternal feces, breast milk, infant feces). Data were represented as mean ± SEM. P values were generated by t-tests. D Distribution of SNPs in the glcU gene respective to its chromosome location. All SNPs in this gene were nonsynonymous