Fig. 3
From: Gut microbiome of helminth-infected indigenous Malaysians is context dependent
Dynamic changes to the gut microbiota of 129 Orang Asli after albendazole treatment. A Line plots show changes of the infection intensity of Trichuris pre and post response to anthelmintic drugs stratified by full responders (n = 43), partial responders (n = 23), nonresponders (n = 5), and uninfected individuals (n = 58). B Principal coordinates analysis (PCoA) plot of Jaccard distances based on gut microbiota profiles (species levels) of responders (ADONIS: p = 0.001, R2 = 0.014; ANOSIM: p = 0.001, R = 0.072), with pre-anthelmintic treatment (blue) and post-anthelmintic treatment (red). C Principal coordinates analysis (PCoA) plot of Jaccard distances based on gut microbiota profiles (species levels) of uninfected subjects (ADONIS: p = 0.006, R2 = 0.012; ANOSIM: p = 0.001, R = 0.069) (Fig. 3C, Supplementary Table S2), with pre-anthelmintic treatment (blue) and post-anthelmintic treatment (red). D Venn diagram depicting the number of shared and exclusive bacteria species that are found to be differentially abundant (pre and post) between responders and uninfected individuals. The blue area includes 253 bacteria that are altered only in responders, while the yellow and mixed color area indicates the 873 bacteria that are altered in uninfected individuals. E Box plots show the bacterial taxa that are altered by deworming treatment in responders but not in nonresponders (host response). The differences in the abundance of (i) Sutterella HRGM Genome 4418 and (ii) Muricomes contorta_B in helminthic infections (left) and different groups of response (right), namely uninfected and responders in pre and post. F Box plots and line plots show the bacterial taxa that are associated with deworming treatment in both responders and nonresponders (drug response). The differences in the abundance of (i) Collinsella sp900540485 and (ii) Collinsella stercoris in helminthic infections (left) and different groups of response (right), namely uninfected and responders in pre and post. The p-values for E and F are computed using Wilcoxon signed-rank test (responders vs nonresponders) and Wilcoxon rank-sum test (helminthic infections)