Fig. 4

Compositional differences of selected species in untreated and vancomycin-treated mice during EAE. Bar plots showing changes in the relative abundance of selected species altered at the indicated time points in A single-treatment housed untreated mice (control) and single-treatment housed vancomycin mice (vancomycin), B single-treatment housed vancomycin mice (vancomycin) and vancomycin-treated mice cohoused with untreated mice (VancoCoho), and C untreated mice cohoused with vancomycin-treated mice (ControlCoho) and vancomycin-treated mice cohoused with untreated mice (VancoCoho). Results are presented as mean ± SEM (n = 11–12 mice/group), *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.001. OTU, operational taxonomic unit; numbers in parenthesis represent OTU. EC1, Enterococcus canintestini/canis/dispar/durans/faecalis/faecium/hirae/lactis/mundtii/ratti/rivorum/villorum; EC2, Enterococcus casseliflavus/gallinarum/saccharolyticus